“I recommend supplemental vitamin C, which helps block the switch, both by stimulating the excretion of uric acid in the urine and blocking the effects of uric acid on the body’s energy factories. Limit the dose to 500 mg to 1,000 mg daily, as higher doses can be associated with an increased risk of kidney stones—another reason to stay well hydrated, as hydration reduces this risk.”

Richard Johnson and David Perlmutter, Nature Wants Us to Be Fat